How Does It Work?
Our products are based off principles of neuroscience and nutrition. All of the ingredients have been carefully selected and researched for their properties.
Having proper brain chemistry balance can improve a lot of different conditions such as low mood, anxiousness, irritability, trouble sleeping, trouble concentrating, addiction, poor memory, lack of motivation, and more. It’s amazing how many problems can resolve themselves when the brain and body have all the resources they need to function at their optimal level. Our comprehensive formulas address the multifaceted issues associated with brain chemistry imbalance.
Our supplements work by:
- Filling in Nutritional Gaps– Providing the body and brain with nutrients that are fundamental for biochemical processes is vital for optimal wellness. Just as you need bricks to build a brick wall, you need the raw materials to build and maintain your brain tissue. In addition to correcting deficiencies, this includes providing precursors materials and enzymatic cofactors so the body can build neurotransmitters, proteins and neuronal structures such as dendrites, synapses and fatty cell membranes.
- Combating Oxidative Stress– Though it is a natural part of life, excessive oxidative stress is essentially what damages our cells (neurons and all). Many plant-based antioxidant compounds in our formulas have been observed to stimulate the Nrf2 pathway, activating genes and promoting the body’s own production of endogenous antioxidant molecules such as glutathione. Activating this pathway by consuming polyphenol rich foods and supplements helps your body combat oxidative stress by neutralizing free radicals with your body’s own supply of antioxidants.
- Healthy Inflammatory Response– Oxidative stress goes hand in hand with inflammation, another driving force of damaging cells and tissue. By promoting a healthy balance of free radicals vs. antioxidant molecules and directly influencing inflammation regulatory genes, our formulas are designed to promote a healthy inflammatory response in the brain and body.
- Promoting Neurogenesis– Studies show that the loss of neurons is associated with cognitive decline, mood disorders and a number of neurodegenerative diseases such as Parkinsons and Alzheimers. Neurogenesis is the growth of new neurons, dendrites and synapses. A growth factor called BDNF (brain derived neurotrophic factor) plays a big role in facilitating the repair, maintenance and growth of new neural networks. Many things can stimulate BDNF and promote neurogenesis such as certain foods/plants, exercise, meditation, and fasting. Scientists agree that promotion of neuronal growth is an important marker of brain and mood health.
All of our products are manufactured in a facility that is certified by the FDA as having G.M.P standards (good manufacturing practices) to ensure quality and safe products you can trust.
Below is information on key ingredients we use in our products, and some explanation to why we chose them. Included are links to peer-reviewed scientific articles supporting the scientific evidence behind our products.
B Vitamins (B3, B6, B9 & B12)
The B vitamins are fundamental for whole body health. They are involved in a number of basic cell repair processes, detoxification pathways, and production of neurotransmitters. B6 is especially important for brain health because of it’s co-factor role in converting a number of molecules to their respective neurotransmitters (serotonin, GABA, dopamine, norepinephrine, and epinephrin). B12, also known as cobalamin, is a vitamin that is important in metabolism, DNA synthesis and regulation, and overall energy production. High B12 levels have shown to have neuroprotective affects against brain atrophy associated with Alzheimers. Vitamin B12 deficiencies can cause symptoms such as fatigue, depression, poor memory and even cause symptoms of mania and psychosis. Folic acid, also known as B9, is fundamental for numerous processes in the body. It cannot be synthesized by the body so adequate intake through food is essential. Folic acid is needed for cell reproduction and synthesis, repair and methylation of DNA. There is a complex relationship between B12, folic acid and Iron. If proper ratios of the 3 aren’t maintained, one can mask a deficiency in another. Niacin (B3) and Riboflavin (B2) are also important B vitamins. Deficiencies in any of the B vitamins can result in fatigue, cognitive impairment and a number of mood disorders and mental illness symptoms.
- Molecular mechanisms of depression: perspectives on new treatment strategies.
- Co-occurrence of anemia, marginal vitamin B6, and folate status and depressive symptoms in older adults.
- Nutrient intakes are correlated with overall psychiatric functioning in adults with mood disorders.
- Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study.
- Does diet affect our mood? The significance of folic acid and homocysteine.
- Treatment of depression: time to consider folic acid and vitamin B12.
- The neurology of folic acid deficiency.
Magnesium is essential to whole body health being critically involved in over 300 functions! It is especially important for brain health. Magnesium has been shown to enhance cognitive abilities. Magnesium contributes to synaptic plasticity, allowing brain cells to recover from stress or trauma faster, and form new synaptic connections. Magnesium is also a NMDA glutamate antagonist. Drugs with the same mechanism of action have shown dramatic promise for treating depression. Because of conventional farming methods and overuse of land, many foods that used to be rich in magnesium are now lacking. Many people have magnesium deficiencies as a result. Supplementing with magnesium contributes to overall health and is a fundamental mineral for the nervous system.
- Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation.
- Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior.
- Rapid recovery from major depression using magnesium treatment.
- Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits.
- Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims.
- Magnesium in depression.
- New paradigms for treatment-resistant depression.
- Platelet serotonin and magnesium concentrations in suicidal and non-suicidal depressed patients.
5-HTP (5-hydroxy-tryptophan) is a chemical intermediate between the amino acid tryptophan and one of it’s end products, serotonin. 5-HTP is more readily converted into serotonin because it is not allocated to other cellular functions as much as tryptophan is, making it more available to be converted directly. It is also able to cross the blood-brain barrier easily, allowing it quick access to the brain where it is transformed into serotonin. Studies have confirmed that 5-HTP ingestion raises serotonin levels, and has efficacy as a treatment for depression/anxiety. Healthy serotonin levels promote calmness, feelings of peace and relaxation. Ideal serotonin levels help modulate sleep, appetite, inflammation, immune response and other neurotransmitter systems.
- Erratum: GTP-cyclohydrolase deficiency responsive to sapropterin and 5-HTP supplementation: relief of treatment-refractory depression and suicidal behaviour.
- The effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats.
- Central and peripheral components of the inhibitory actions of 5-HTP on ethanol consumption in the rat.
- In search of the mode of action of antidepressants: 5-HTP/tyrosine mixtures in depression.
Tyrosine is a non-essential amino acid that is fundamental to a number of processes in the body. It is the precursor that gets converted into neurotransmitters dopamine, norepinephrine and epinephrine. These class of neurotransmitters, called catecholamines are important for regulating cognition, alertness, mood and behavior. Tyrosine is considered a conditional amino acid because it exerts its effects only when a localized deficiency state exists thus it’s effects seem to be system specific and occur only when needed, such as when dopamine or norepinephrin levels are expended. Deficiencies in these catecholamine neurotransmitters are linked to depression, anxiety, fatigue, poor cognitive performance, impulsive behavior and dementia/Alzheimer’s disease. L-Tyrosine has shown efficacy in supporting brain resilience during stress which has implications in preventing depression that may be triggered or augmented by stress.
L-theanine is a naturally occurring amino acid, mostly found in green and black tea plants. It has been found to be useful in improving mood, promoting calmness, reducing feelings of anxiety, and enhancing concentration. Unlike other calming agents, L-theanine does not cause drowsiness. Naturally occurring in caffeinated teas, it is known to “take the edge off” of stimulants such as caffeine, balancing out the excitable effects. It is an analogue of the excitatory neurotransmitter, glutamate. L-theanine can block or activate certain glutamate receptors in the brain, possibly preventing damaging effects from excessive glutamate excitation of neurons. This may be a mechanism for it’s neuroprotective properties. It also increases levels of Serotonin, dopamine and GABA in the brain. It also has been found to increase levels of BDNF (Brain derived neurotrophic factor), promoting growth and repair of dendrites and synapses in brain cells, as well as forming new neurons.
- The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent.
- L-theanine, a natural constituent in tea, and its effect on mental state.
- l-Theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain.
- Effect of L-theanine on glutamatergic function in patients with schizophrenia.
- Serum Levels of Brain-Derived Neurotrophic Factor and Cortisol to Sulfate of Dehydroepiandrosterone Molar Ratio Associated With Clinical Response to l-Theanine as Augmentation of Antipsychotic Therapy in Schizophrenia and Schizoaffective Disorder Patients
- Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression.
Turmeric (Curcuma longa) is a spice that’s been used in Ayurvedic medicine and food for thousands of years in Asian countries. It contains a group of polyphenolic compounds called curcuminoids. The most researched of these compounds is curcumin. Turmeric has been found to exhibit anti-cancerous, antifungal, antibacterial, anti-inflammatory, neuroprotective, and antioxidant properties. We chose turmeric as one of our ingredients because of it’s affect on inflammatory response, antioxidant production in the body, and ability to promote neurogenesis. Stress, sleep deprivation, and toxins can cause oxidative stress and tissue damage to our body and brains. Turmeric promotes a healthy inflammatory response and helps the body recover to optimal function. Turmeric increases levels of antioxidant vitamins in the body such as vitamin C and E, and is a strong stimulator of the Nrf2 pathway that promotes endogenous antioxidant production, combating oxidative damage to cells and DNA Turmeric also promotes a protein called BDNF, which regulates brain cell and dendrite growth. Turmeric has been clinically shown to increase BDNF in hippocampal regions of the brain.
- Curcumin exhibits anti-pre-cancer activity by increasing levels of vitamins C and E, and preventing lipid peroxidation and DNA damage.
- Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression
- Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue.
- Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action.
- Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats.
- Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats.
- Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF.
- Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects.
Spirulina is blue-green algae, composed of two species of Arthrospira. It is considered a complete protein, meaning it contains all 9 of the essential amino acids. This includes L-tryptophan, which can be converted into serotonin, and also L-phenylalanine and L-tyrosine, which can be converted into dopamine. It also contains the omega-3 fatty acid, alpha linolenic acid, which has neuroprotective effects, can aid in managing depression, and contributes to overall brain health. Spirulina contains a number of vitamins and minerals, with especially high amounts of B vitamins and iron. Spirulina is also useful for preventing oxidative damage, promoting stem cell genesis, and preventing memory loss.
- A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson’s disease.
- Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated mice.
- Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.
- Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system.
- Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines.
- Antioxidant activity of the microalga Spirulina maxima.
The fruit of the blueberry plant (Vaccinium) contains a number of powerful antioxidants and phytochemicals which have many health benefits. Blueberries contain anthocyanins which evidence has shows reduces inflammation, may help fight cancer, reverse aging, and improve memory and depression symptoms. Blueberry compounds, like turmeric, also contribute to neurotrophic cell proliferation by activating BDNF and promoting neurogenesis in the hippocampal region of the brain. They also provide protection against neurotoxicity and DNA damage. Like Turmeric, blueberry compounds stimulate the bodies antioxidant production by interacting with regulatory genes helping your body combat oxidative stress. Blueberry also interacts with inflammation regulating genes and has been clinically shown to prevent cognitive decline and memory loss.
- Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro.
- Nutraceutical Intervention Improves Older Adults’ Cognitive Functioning.
- Blueberry (Vaccinium virgatum) leaf extracts protect against Aβ-induced cytotoxicity and cognitive impairment.
- Chemical analysis and effect of blueberry and lingonberry fruits and leaves against glutamate-mediated excitotoxicity.
- Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.
- A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress.
- Synaptic failure and adenosine triphosphate imbalance induced by amyloid-β aggregates are prevented by blueberry-enriched polyphenols extract.
- Behavioral and genoprotective effects of Vaccinium berries intake in mice.
- Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract.
Ashwagandha (Withania somnifera) has been traditional used as an ayurvedic herb for over 4,000 in ayurvedic medicine. It is considered an adaptogen because of it’s remarkable ability to assist in maintaining homeostasis in the body during stress or changes in environment. It has neuroprotective and hormone balancing properties and also promotes resilience and recovery from stress. It contains compounds called withanolides that have shown to increase neurotransmitter activity, improve protein synthesis, boost antioxidant activity and promote a healthy inflammatory response. Ashwaganda also protects against glutamate-mediated excitotoxicity which can cause damage to neurons and dysregulation of other neurotransmitter systems.
- A biologically active constituent of withania somnifera (ashwagandha) with antistress activity
- C6 and IMR-32 Cells against Glutamate-Induced Excitotoxicity
- β-Amyloid1-42, HIV-1Ba-L (Clade B) Infection and Drugs of Abuse Induced Degeneration in Human Neuronal Cells and Protective Effects of Ashwagandha (Withania somnifera) and Its Constituent Withanolide A
- An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera)
- Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases
- Alteration in the sensitivity of 5HT receptor subtypes following chronic Ashwagandha treatment in rats.
Passionflower (Passiflora incarnate) has been used traditionally to treat anxiety and insomnia. Studies show that Passiflora extracts not only contain a high amount of GABA, but are also able to induce direct GABA currents via activation of GABA receptors in the hippocampus. GABA has a calming effect on the nervous system and is the category of receptors that many anti-anxiety medications target. Most species of passion flower also contain beta-carboline harmala alkaloids as well as. Some of these have MAOI activity, mildly increasing levels of certain neurotransmitters. Passion flower extracts also show potential in aiding in the treatment of addictive drug withdrawals (opiates, nicotine etc.) Studies of people with generalized anxiety disorder show that passionflower is as effective as the drug oxazepam (Serax) for treating symptoms.
- Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam.
- Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method
- Passion flower extract antagonizes the expression of nicotine locomotor sensitization in rats.
- Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser
- Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review
Lemon balm (Melissa officinalis) has been used historically for over 2,000 years to improve disorder of the brain and nervous system. Research suggests that lemon balm can improve mood and cognitive performance as well reduce symptoms of insomnia, anxiety and the harmful effects of stress. Like passion flower, Lemon balm is suspected to produce an anxiolytic (anti-anxiety) and calming effects by increasing GABA activity in the brain. Speculations suggest that it may inhibit an enzyme that breaks down GABA, resulting in elevated levels. Some strains have also shown cholinergic activity, likely contributing to improvements in memory and cognitive effects.
- Anti-Stress Effects of Lemon Balm-Containing Foods
- Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties.
- Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).
- Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances
- Melissa officinalis and Passiflora caerulea infusion as physiological stress decreaser
Milk Thistle (Silybum marianum) has been used traditionally in Chinese medicine to treat the liver. It contains many pharmacologically active compounds including Silymarin and Silibinin. Research suggests that compounds from Milk Thistle stimulate regeneration of liver cells, stimulate detoxification pathways, stabilize cell members, and inhibit growth of cancer cells. It also has been found to boost antioxidant production in the body. Research suggest that consuming Milk Thistle increases levels of serotonin, norepinephrin and BDNF (brain derived neurotrphic factor). Milk Thistle extracts have also been found to enhance protein synthesis, and have inflammatory and immune modulating activity. Silymarin shows evidence of neuroprotective properties in neurodegenerative diseases and stress-induced damage in neurons. Liver health is very important for brain and mood health because of it’s important role in detoxification of organs, regulation of hormones and enzyme production which effects nutrient metabolism.
- Protective effects of silibinin and its possible mechanism of action in mice exposed to chronic unpredictable mild stress.
- Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives.
- Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease via mitochondrial stabilization.
- Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice.
- Silymarin effect on amyloid-β plaque accumulation and gene expression of APP in an Alzheimer’s disease rat model.
Black pepper, from the plant Piper nigrum, contains a polyphenolic compound called Piperine. Piperine has been clinically shown to improve the absorption of nutrients when taken with food or other supplements. It is also a strong antioxidant and anti-inflammatory compound. Piperine has also been found to be an effective pain reducing agent. Black pepper also aids in digestion and detoxification. Piperine can inhibit certain enzymes that break down compounds in the body, resulting in elevated levels of neurotransmitters and better absorption of circulating nutrients, phytochemicals or drugs from the blood stream.
- Antioxidative properties and inhibition of key enzymes relevant to type-2 diabetes and hypertension by essential oils from black pepper.
- Synthesis and characterization of nano-encapsulated black pepper oleoresin using hydroxypropyl beta-cyclodextrin for antioxidant and antimicrobial applications.
- Antioxidant potential of spices and their active constituents.
- Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease.
- Piperine, a dietary phytochemical, inhibits angiogenesis.