What is ZenBiotic?
ZenBiotic is a neuroscientist-developed comprehensive probiotic and prebiotic supplement designed to support a healthy brain and happy mood. By supporting a balanced gut microbiome, Zenbiotic can improve digestive, immune and mental health. ZenBiotic contains 11 probiotic strains, prebiotics, and gut supporting vitamin D3 and N-acetyl-cysteine, all in a delayed-release capsule, to ensure that they reach their destination in the intestines. All probiotic species were chosen based on scientific research exhibiting positive effects on neurotransmitter production, resilience to stress, reduction in depressive behaviors, and regulation of the HPA (Hypothalamas-pituitary-adrenal) axis mediated stress response.
The Gut-Brain Relationship
Emerging research has shown that the brain and gut are intimately linked and communicate with each other. This communication network is called the ‘gut-brain axis’. The gut contains millions of nerve cells that transmit information to and from the brain. To give you some perspective, there are more nerve cells in the gastrointestinal tract than there are in the spinal chord. Recent science has discovered that the population of organisms in our gut called the microbiome, have dramatic influence on mental health and wellbeing.
Did you know that 90% of our body’s neurotransmitters such as serotonin and dopamine are made in the gut? Many of the bacteria, fungi and archaea in our gut play crucial roles in regulating neurotransmitter production, nutrient extraction, formation of B vitamins, inflammation, immune response and protection from pathogenic bacteria. When the populations of microbes in our intestines become imbalanced, we can experience depression, anxiety, low energy, increased pain, brain fog, digestive issues, food allergies and the development of autoimmune conditions.
With the discovery of the importance of the gut microbiome to psychiatric health, a new route for probiotic supplements emerge as “psychobiotics”. The science suggests that the future of addressing mental conditions in not so much in our brains, but actually in our guts.
In addition to 6 lactobaccilus and 3 bifidobacterium species, ZenBiotic contains two clinically studied strains of Baccilus as B. subtilis DE111 and B. coagulans Lactospore. Bacillus bacteria are spore-forming, meaning they can withstand heat and stomach acid and survive until they reach the intestine, where they then proliferate very successfully. Baccilus are soil-based organisms, and have remained virtually unchanged by evolution for millions of years. They have an amazing ability to restore balance in the microbiome, by intelligently discerning between overgrown or pathogenic bacteria, and “good” bacteria. Promising research shows they have a huge capacity to reduce intestinal permeability or “leaky gut” which appears to be a driving mechanism for the development of autoimmune conditions. Some Baccilus species have also been discovered as the first known probiotic to create antioxidant molecules such as beta-carotene, Lycopene, Lutein, Astaxanthin, Zeaxanthin. Presence of sporeforming baccilus strains in ZenBiotic provides protective effects to the other non-spore forming species, giving them improved survival of heat and stomach acid.
ZenBiotic contains a cutting-edge phage technology complex that acts a novel type of prebiotic. Phages are bacteria-specific viruses. The FDA approved strains in ZenBiotic target specific strains of E. Coli that are pathogenic and inhibit the growth of commensal or “good” gut bacteria. The phages kill the E. Coli, freeing up space in the gut for good guys to inhabit, and spill out the E. Coli’s cellular contents, which act as a nutrient fertilizer feeding surrounding good bacteria. Studies show that combining phages with probiotics can yield a 10-40 time increase in the amount of good gut bacteria in the colon and feces. PreforPro patented phage technology does not feed bad bacteria and cause bloating or gas like other prebiotic fibers.
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Meet the Microbes!
- Plantarum is a lactid acid producing bacteria. It is commonly found in plant matter and fermented foods. L. Plantarum PS128 creates neurotransmitters serotonin, dopamine and acetylcholine as a metabolite byproducts. L. Plantarum has been observed in studies to reduce depression-like behavior in those with early-life stress. L. Plantarum PS128 is also known for regulating the stress hormone, cortisol through the HPA (hypothalamus-pituitary-adrenal-axis), normalizing the stress response system. Studies suggest that L. plantarum C29 may improve memory due to the acetylecholine production. Studies have also shown that L. plantarum C29 can mediate the release of pro-inflammatory molecules called cytokines, as well as reduce the amount of LPS endotoxin in the gut by promoting intestinal flora balance.
- Helveticus is a probiotic species that has been extensively studied for it’s effects on mood and stress. When compared to the SSRI citalopram, L. helveticus NS8 worked better than the drug in reducing chronic stress-induced depression, anxiety, and cognitive dysfunction. L. Helveticus R0052 reduced cortisol levels and returned serotonin and other brain chemicals to normal levels after the stress by regulating the HPA axis (hypothalamus-pituitary-adrenal) stress response. There is evidence that strains of L. Helveticus may decrease neuroinflammation.
- longum 1714 has been observed to reduce anxiety-like behavior, improve mood in anxious animal models, improve cognitive performance, and reduce cortisol levels and mitigate the effects of stress.
- acidophilus is a widely used probiotic species from the Lactobacillus genus. The name is based on the latin translation of acid-loving, milk-bacillus. L. acidophilus is a gram positive bacteria that plays a foundational role in the human gut, mouth and vaginal microbiome. It grows best in acidic environments with a pH of lower than 5, and is often used to culture dairy products such as yoghurt and kefir.
Research of certain strains of L. acidophilus suggest that it can contribute to upregulating CB2 endocannabinoid and mu-opioid receptors in the gut, leading to improved mood and resilience to stress. It has also shown promise in inhibiting the cell adhesion of Campylobacter jejuni, a bacteria associated with poor gut health in humans and the ability to cause anxiety behavior in mice.
- coagulans is a spore-forming bacteria that is soil-based. The Baccilus species are notoroious for their ability to survive heat, stomach acid, and transport and colonize effectively in the human gut. Like B subtilis, B coagulans has been observed to increase the growth of beneficial bacteria in the gut, as well as increase anti-inflammatory cytokines. Baccilus species are like the composers, while the other beneficial bacteria are the orchestra. B coagulans supports a healthy balance of intestinal microbes, promoting a healthy immune system, nervous system, and digestion.
- rhamnosus R0011 was found to normalize anxiety-like behavior and learning and memory deficits in immune-deficient mice with HPA (hypothalamus-pituitary-adrenal axis dysfunction. studies.) L. Rhamnosus JB-1 was found to alter the mRNA expression of both Gaba A and GABA B receptors, creating implications for it’s role in alleviate anxiety and depression.
B subtilis is spore-forming species that is known for colonizing and proliferating effectively in the human gut. They are soil based organism that are known for surviving heat, transport, and stomach acid. B subtilis spores can survive up to 6 years in space! Studies suggest that the presence of B. subtilis can normalize gut dysbiosis, especially after antibiotic use. Other studies has shown that B. subtilis causes an increase in BNDF (brain-derived-neurotrophic-factor) promoting regeneration and repair of brain cells and neuronal structures such as dendrites and synapses. It also has been found to alleviate oxidative stress, which is a huge driver in neuroinflammation.
B subtilis has been used in livestock extensively as an alternative to antibiotics. It has been observed to increase growth of beneficial bacteria such as bifidobacteria and L. acidophilus, while reducing pathogenic bacteria such as clostridium and H. pylori.
- brevis is a probiotic that is very effective at converting glutamate into GABA, promoting a healthy balance of neurotransmitters. Increased GABA can be effective for reducing anxiety and boosting mood. In a study comparing L. brevis FPA3709 to fluoxetine, L. brevis was equally effective but did not create the side-effects that came with fluoxetine.
Bifidobacteria animalis lactis
Formerly known as L. infantis, L animalis lactis 35624 was found to increase serum levels of tryptophan, a precursor to serotonin. A reduction is depressive-like behaviors were observed and was comparable to the SSRI drug citalopram. Researchers observed modulation of serotonin and dopamine transmission, as well as an anti-inflammatory effect.
- casei Shirota strain has been studied for it’s effects on reducing anxiety. In a study using stressed medical students as subjects, L. casei (LcS) prevented stress-related cortisol increase and increased serotonin levels. It was also found to reduce anxiety in patients with Chronic Fatigue Syndrome. L casei (LcS) also appears to promote the growth of lactobaccilus and Bifidobacteria species in the gut, as well as inhibiting the growth of some pathogenic bacteria such as H. pylori.
- breve shows clinical evidence for reducing anxiety and improving cognitive performance. It also inhibits and prevents the growth of pathogenic organisms such as candida albicans (yeast) and certain strains of E. coli. A deficiency of B breve was found to be associated with allergies, flatulence, diarrhea and Irritable Bowel Syndrome (IBS).
A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood.
Lactobacillus and Bifidobacterium Ameliorate Memory and Learning Deficits and oxidative stress in Aβ (1-42) Injected Rats.