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Sound like you?

• Sleep deprivation

• Chronic Stress

• Feelings of depression, anxiety or irritability

• Over-stimulation

• Use of caffeine, alcohol or other drugs

• Over exertion

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Stress Can Contribute to:

• Depletion of neurotransmitters, minerals, enzymes, antioxidants and more

• Oxidative damage to cells (free radicals).

• Inflammation in the brain and body.

• Insomnia, exhaustion, pain, headache, and feelings of sadness, anxiety or irritability.

• Metabolic changes (weight gain or loss)

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Optimal brain health and resilience is the secret to combating stress. When equipped with the resources it needs, the brain is remarkable at rebalancing and repairing it’s self when the body undergoes a stress response. While obviously eliminating the source of the stress is the best way to fight it, that’s not always under our control. the next best thing we can do is give our body the raw materials to adapt to and repair the damage that stress does to our brains. This formula was designed by applying these cutting-edge neuroscience concepts to support optimal brain resilience from physical and mental stress.

• • • Filling in Nutritional Gaps- Providing the body and brain with nutrients that are fundamental for biochemical processes is vital for optimal wellness. Stress can rapidly deplete levels of neurotransmitters, enzymes, minerals and other key nutrients in the body. Just as you need bricks to build a brick wall, you need the raw materials to build and maintain your brain tissue.  In addition to correcting deficiencies, this includes providing precursors materials and enzymatic cofactors for the body to build neurotransmitters, proteins and neuronal structures such as dendrites, synapses and fatty cell membranes. A brain that has the materials to repair it’s self is much more resilient to stress, toxins and environmental changes.
  • • Combating Oxidative Stress- Though it is a natural part of life, oxidative stress is essentially what damages our cells (neurons and all). Excessive activation and stress in the nervous system increases damage from oxidative stress by increasing the amount of free-radicals released and depleting antioxidants that neutralize them. Many plant-based antioxidant compounds in our formulas have been observed to stimulate the Nrf2 pathway, activating genes and promoting the body’s own production of endogenous antioxidant molecules such as glutathione. Activating this pathway by consuming polyphenol rich foods and supplements helps your body combat oxidative stress by neutralizing the free radicals with your body’s supply of antioxidants.
  • • Healthy Inflammatory Response– Oxidative stress goes hand in hand with inflammation, another driving force of damaging cells and tissue. By promoting a healthy balance of free radicals vs. antioxidant molecules and directly influencing inflammation regulatory genes, our formulas are designed to promote a healthy inflammatory response in the brain and body.
  • • Promoting Neurogenesis- Many studies show a trend that loss of neurons are associated with cognitive decline, mood disorders and a number of neurodegenerative diseases such as Parkinsons and Alzheimers. Neurogenesis is the growth of new neurons, dendrites and synapses. Sleep deprivation is one of the biggest assaults to our brain, resulting in damage to brain cells and atrophy of brain tissue. Elevated stress hormone also wreaks havoc on our brains ability to perform neurogenesis. A growth factor called BDNF (brain derived neurotrophic factor) plays a big role in facilitating the repair, maintenance and growth of new neural networks. Many things can stimulate BDNF and promote neurogenesis such as certain foods/plants, exercise, meditation, fasting and more. Scientists agree that promotion of neuronal growth is an important marker of brain and mood health.

Ingredients

Learn about all the amazing ingredients we chose to add to ReVive. Click on “ingredient Information” or “Scientific References” to open.

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[fusion_title size=”2″]B Vitamins (B3, B6, B9 & B12)[/fusion_title]

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The B vitamins are fundamental for whole body health. They are involved in a number of basic cell repair processes, detoxification pathways, and production of neurotransmitters. B6 is especially important for brain health because of it’s co-factor role in converting a number of molecules to their respective neurotransmitters (serotonin, GABA, dopamine, norepinephrine, and epinephrin). B12, also known as cobalamin, is a vitamin that is important in metabolism, DNA synthesis and regulation, and overall energy production. High B12 levels have shown to have neuroptrotective affects against brain atrophy associated with Alzheimers. Vitamin B12 deficiencies can cause symptoms such as fatigue, depression, poor memory and even cause symptoms of mania and psychosis. Folic acid, also known as B9, is fundamental for numerous processes in the body. It cannot be synthesized by the body so adequate intake through food is essential. Folic acid is needed for cell reproduction and synthesis, repair and methylation of DNA. There is a complex relationship between B12, folic acid and Iron. If proper ratios of the 3 aren’t maintained, one can mask a deficiency in another. Niacin (B3) and Riboflavin (B2) are also important B vitamins. Deficiencies in any of the B vitamins can result in fatigue, cognitive impairment and a number of mood disorders and mental illness symptoms.

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[fusion_toggle title=”Scientific References (LINKS)” open=”no”]

• 1. Molecular mechanisms of depression: perspectives on new treatment strategies.
  2. Co-occurrence of anemia, marginal vitamin B6, and folate status and depressive symptoms in older adults.
  3. Nutrient intakes are correlated with overall psychiatric functioning in adults with mood disorders.
  4. Vitamin B12 status in patients of Turkish and Dutch descent with depression: a comparative cross-sectional study.
  5. Does diet affect our mood? The significance of folic acid and homocysteine.
  6. Treatment of depression: time to consider folic acid and vitamin B12.
  7. The neurology of folic acid deficiency.[/fusion_toggle]

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[fusion_title size=”2″]Magnesium[/fusion_title]

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Magnesium is essential to whole body health being critically involved in over 300 functions! It is especially important for brain health. Magnesium has been shown to enhance cognitive abilities. Magnesium contributes to synaptic plasticity, allowing brain cells to recover from stress or trauma more easily, and form new synaptic connections. Magnesium is also a NMDA glutamate antagonist. Drugs with the same mechanism of action have shown dramatic promise for treating depression. Because of conventional farming methods and overuse of land, many foods that used to be rich in magnesium are now lacking. Many people have magnesium deficiencies as a result. Supplementing with magnesium contributes to overall health and is a fundamental mineral for the nervous system.

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• 1. Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation.
  2. Changes in brain protein expression are linked to magnesium restriction-induced depression-like behavior.
  3. Rapid recovery from major depression using magnesium treatment.
  4. Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits.
  5. Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims.
  6. Magnesium in depression.
  7. New paradigms for treatment-resistant depression.
  8. Platelet serotonin and magnesium concentrations in suicidal and non-suicidal depressed patients. [/fusion_toggle]

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[fusion_title size=”2″]5-HTP (5-hydroxy-tryptophan)[/fusion_title]

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5-HTP (5-hydroxy-tryptophan) is a chemical intermediate between the amino acid tryptophan and one of it’s end products, serotonin. 5-HTP is more readily converted into serotonin because it is not allocated to other cellular functions as much as tryptophan is, making it more available to be converted directly. It is also able to cross the blood-brain barrier easily, allowing it quick access to the brain where it is transformed into serotonin. Studies have confirmed that 5-HTP ingestion raises serotonin levels, and has efficacy as a treatment for depression/anxiety. Healthy serotonin levels promote calmness, feelings of peace and relaxation. Ideal serotonin levels help modulate sleep, appetite, inflammation, immune response and other neurotransmitter systems.

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• • 1. Erratum: GTP-cyclohydrolase deficiency responsive to sapropterin and 5-HTP supplementation: relief of treatment-refractory depression and suicidal behaviour.
    2. The effect of oral 5-HTP administration on 5-HTP and 5-HT immunoreactivity in monoaminergic brain regions of rats.
    3. Central and peripheral components of the inhibitory actions of 5-HTP on ethanol consumption in the rat.
    4. In search of the mode of action of antidepressants: 5-HTP/tyrosine mixtures in depression.[/fusion_toggle]

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[fusion_title size=”2″]Turmeric[/fusion_title]

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Turmeric (Curcuma longa) is a spice that’s been used in Ayurvedic medicine and food for thousands of years in Asian countries. It contains a group of polyphenolic compounds called curcuminoids. The most researched of these compounds is curcumin. Turmeric has been found to exhibit anti-cancerous, antifungal, antibacterial, anti-inflammatory, neuroprotective and antioxidant properties. We chose turmeric as one of our ingredients because of it’s affect on inflammatory response, antioxidant production in the body, and ability to promote neurogenesis. Stress, sleep deprivation, and toxins can cause oxidative stress and tissue damage to our body and brains. Turmeric promotes a healthy inflammatory response and helps the body recover to optimal function. Turmeric increases levels of antioxidant vitamins in the body such as vitamin C and E, and is a strong stimulator of the Nrf2 pathway that promotes endogenous antioxidant production, combating oxidative damage to cells and DNA Turmeric also promotes a protein called BDNF, which regulates brain cell and dendrite growth. Turmeric has been clinically shown to increase BDNF in hippocampal regions of the brain.

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• • 1. Curcumin exhibits anti-pre-cancer activity by increasing levels of vitamins C and E, and preventing lipid peroxidation and DNA damage.
    2. Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression
    3. Curcuma longa extract associated with white pepper lessens high fat diet-induced inflammation in subcutaneous adipose tissue.
    4. Antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action.
    5. Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats.
    6. Neuroprotective and antioxidant effects of curcumin in a ketamine-induced model of mania in rats.
    7. Antidepressant-like effects of curcumin in WKY rat model of depression is associated with an increase in hippocampal BDNF.
    8. Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects.[/fusion_toggle]

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[fusion_title size=”2″]Spirulina[/fusion_title]

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Spirulina is blue-green algae, composed of two species of Arthrospira. It is considered a complete protein, meaning it contains all 9 of the essential amino acids. This includes L-tryptophan, which can be converted into serotonin, and also L-phenylalanine and L-tyrosine, which can be converted into dopamine. It also contains the omega-3 fatty acids, alpha linolenic acid and Alpha Lipoic Acid (ALA), which have neuroprotective effects, can aid in managing depression, and contributes to overall brain health. Spirulina contains a number of vitamins and minerals, with especially high amounts of B vitamins and iron. Spirulina is also useful for preventing oxidative damage, promoting stem cell genesis, and preventing memory loss.

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• • 1. A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson’s disease.
    2. Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated mice.
    3. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.
    4. Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system.
    5. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines.
    6. Antioxidant activity of the microalga Spirulina maxima.[/fusion_toggle]

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[fusion_title size=”2″]Blueberry[/fusion_title]

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The fruit of the blueberry plant (Vaccinium) contains a number of powerful antioxidants and phytochemicals which have many health benefits. Blueberries contain anthocyanins which evidence has shows reduces inflammation, may help fight cancer, reverse aging, and improve memory and depression symptoms. Blueberry compounds, like turmeric, also contribute to neurotrophic cell proliferation by activating BDNF and promoting neurogensis in the hippocampal region of the brain. They also provide protection against neurotoxicity and DNA damage. Also like Turmeric, blueberry compounds stimulate the bodies antioxidant production by interacting with regulatory genes helping your body combat oxidative stress. Blueberry also interacts with inflammation regulating genes and has been clinically shown to prevent cognitive decline and memory loss.

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• • 1. Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro.
    2. Nutraceutical Intervention Improves Older Adults’ Cognitive Functioning.
    3. Blueberry (Vaccinium virgatum) leaf extracts protect against Aβ-induced cytotoxicity and cognitive impairment.
    4. Chemical analysis and effect of blueberry and lingonberry fruits and leaves against glutamate-mediated excitotoxicity.
    5. Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.
    6. A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress.
    7. Synaptic failure and adenosine triphosphate imbalance induced by amyloid-β aggregates are prevented by blueberry-enriched polyphenols extract.
    8. Behavioral and genoprotective effects of Vaccinium berries intake in mice.
    9. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract.[/fusion_toggle]

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[fusion_title size=”2″]Black Pepper[/fusion_title]

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Black pepper, from the plant Piper nigrum, contains a polyphenolic compound called Piperine. Piperine has been clinically shown to improve the absorption of nutrients when taken with food or other supplements. It is also a strong antioxidant and anti-inflammatory compound. Piperine has also been found to be an effective pain reducing agent. Black pepper also aids in digestion and detoxification. Piperine can inhibit certain enzymes that break down compounds in the body, resulting in elevated levels of neurotransmitters and better absorption of circulating nutrients, phytochemicals or drugs from the blood stream.

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• • 1. Antioxidative properties and inhibition of key enzymes relevant to type-2 diabetes and hypertension by essential oils from black pepper.
    2. Synthesis and characterization of nano-encapsulated black pepper oleoresin using hydroxypropyl beta-cyclodextrin for antioxidant and antimicrobial applications.
    3. Antioxidant potential of spices and their active constituents.
    4. Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson’s disease.
    5. Piperine, a dietary phytochemical, inhibits angiogenesis.[/fusion_toggle]

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[fusion_title size=”2″]Milk Thistle[/fusion_title]

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Milk Thistle (Silybum marianum) has been used traditionally in chinese medicine to treat the liver. It contains many pharmacologically active compounds including Silymarin and Silibinin. Research suggests that compounds from milkthistle stimulate regeneration of liver cells, stimulate detoxification pathways, stabilize cell members, and inhibit growth of cancer cells. It also has been found to boost antioxidant production in the body. Research suggest that consuming milk thistle increases levels of serotonin, norepinephrin and BDNF (brain derived neurotrphic factor). Milkthistle extracts have also been found to enhance protein synthesis, and have inflammatory and immune modulating activity. Silymarin shows evidence of neuroprotective properties in neurodegenerative diseases and stress-induced damage in neurons. Liver health is very important for brain and mood health because of it’s important role in detoxification of organs, regulation of hormones and enzyme production which effects nutrient metabolism.

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• • 1. 1. Protective effects of silibinin and its possible mechanism of action in mice exposed to chronic unpredictable mild stress.
       2. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives.
       3. Silibinin prevents dopaminergic neuronal loss in a mouse model of Parkinson’s disease via mitochondrial stabilization.
       4. Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice.
       5. Silymarin effect on amyloid-β plaque accumulation and gene expression of APP in an Alzheimer’s disease rat model.

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Testimonials

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Our products are manufactured in an facility that is certified by the FDA as having G.M.P (Good Manufacturing Practices) standards.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, cure, treat or prevent any disease.

Warning: If you are pregnant, nursing or have any medical condition, consult your physician before use. Discontinue use if any adverse reaction occur.

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